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KMID : 0385019940100020253
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Korean Journal of Laboratory Animal Science
1994 Volume.10 No. 2 p.253 ~ p.259
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The Local Irritation Test of LBD-008
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Abstract
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This study was performed to examine the local irritation of LBD-008. With the volume of 1㎖ at the concentration of 20 ㎍/㎖ which is expected clinical dose in human, two groups of rabbit were injected subcutaneously on back and intramuscularly in Vastus lateralis muscle once or 5 times for 5 days. And the other groups of rabbits were injected intravenously once with 1㎖ of saline or test material. For positive control material, 6% or 0.75% acetic acid was used, and for negative saline.
The results were as followed:
1. In all groups except positive control, no clinical sign was shown in all rabbits.
2. In the groups of rabbits injected 5 times in muscle and subcutaneous tissue with LBD-008 or saline, There were the limited and slight histopatholagical changes in berth site of test material and saline.
From the results of these, we conclude that LBD-008 was not to be irritant on rabbit´s muscle and subcutaneous tissue at the concentration of 20 ㎍/㎖.
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